(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

Base Information

Chemical Name:(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin
CAS No.:330206-79-6
Molecular Formula:C₂₂H₂₄FNO
Molecular Weight:337.437
Hs Code.:

Synonyms:(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

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Chemical Property of (R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

Chemical Property:

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Technology Process of (R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

There total 3 articles about (R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 330206-76-3
2-(4-fluoro-phenyl)-N-(7-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-prop-2-ynyl-acetamide

: 330206-79-6
(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;

Reference yield:

: 4133-34-0
7-methoxyl-2-tetralone

: 330206-79-6
(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / sodium triacetylborohydride; AcOH / 1,2-dichloro-ethane / 20 °C

2: 59 percent / Et₃N / CH₂Cl₂ / 3 h

3: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With sodium triacetoxy borohydride; lithium aluminium tetrahydride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 159427-84-6
(R,S)-trans-7-methoxy-2-[N-(propynyl)amino]tetralin

: 330206-79-6
(R,S)-trans-7-methoxy-2-[N-propynyl-N-ethyl-(4'-fluorophenyl)amino]tetralin

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / Et₃N / CH₂Cl₂ / 3 h

2: 82 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;