1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

Base Information

Chemical Name:1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide
CAS No.:1449319-05-4
Molecular Formula:C₁₈H₁₃ClFN₅O
Molecular Weight:369.786
Hs Code.:

Synonyms:1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

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Chemical Property of 1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

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Technology Process of 1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

There total 1 articles about 1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.1%

: 401647-24-3
1-benzyl-1H-pyrazole-4-carboxylic acid

: 1196507-37-5
5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-ylamine

: 1449319-05-4
1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

Guidance literature:: With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1449319-05-4
1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: C₂₈H₃₂ClN₇O₃

Guidance literature:: In butan-1-ol; at 160 ℃; for 6h; Microwave irradiation;

Reference yield:

: 1449319-05-4
1-benzyl-1H-pyrazol-4-carboxylic acid (5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide

: 1449319-00-9
N-{4-[(3R)-3-aminopiperidin-1-yl]-5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}-1-benzyl-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / 6 h / 160 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With trifluoroacetic acid; In dichloromethane; butan-1-ol;