C₁₈H₂₁NOS₂

Base Information

• Chemical Name: C₁₈H₂₁NOS₂
• CAS No.: 1352317-59-9
• Molecular Formula: C₁₈H₂₁NOS₂
• Molecular Weight: 331.503

Synonyms:C₁₈H₂₁NOS₂

Chemical Property of C₁₈H₂₁NOS₂

Chemical Property:

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Technology Process of C₁₈H₂₁NOS₂

There total 1 articles about C₁₈H₂₁NOS₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromo-2-picoline (38749-79-0) → C18H21NOS2 (1352317-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / diethyl ether; hexane / 2 h / -20 °C / Inert atmosphere

1.2: 1 h / -20 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium diisopropyl amide; In diethyl ether; hexane; toluene; 2.1: Buchwald-Hartwig cyclization;

DOI:10.1016/j.tet.2011.10.028

Reference yield:

C18H21NOS2 (1352317-59-9) → (1'R,7a'S)-7a'-methyl-5'-phenyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-indene] (1352317-69-1)

Guidance literature:

Multi-step reaction with 3 steps

1: water; bis-[(trifluoroacetoxy)iodo]benzene / tetrahydrofuran; methanol; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water; toluene / 3 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 3: Suzuki coupling;

DOI:10.1016/j.tet.2011.10.028

Reference yield:

C18H21NOS2 (1352317-59-9) → 4-((1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl)phenol (1352317-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: water; bis-[(trifluoroacetoxy)iodo]benzene / tetrahydrofuran; methanol; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / -20 - 0 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water; toluene / 3 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 3: Suzuki coupling;

DOI:10.1016/j.tet.2011.10.028

upstream raw materials:

3-bromo-2-picoline

Downstream raw materials:

(1'R,7a'S)-7a'-methyl-5'-phenyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-indene]

4-((1'R,7a'S)-7a'-methyl-2',6',7',7a'-tetrahydro-3H-spiro[furo[3,2-b]pyridine-2,1'-inden]-5'-yl)phenol

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