2,3-Dimethoxy-5-methylphenol

Base Information

• Chemical Name: 2,3-Dimethoxy-5-methylphenol
• CAS No.: 1128-32-1
• Molecular Formula: C9H12 O3
• Molecular Weight: 168.192
• Hs Code.: 2909500000
• European Community (EC) Number: 214-437-1
• UNII: T26EB3VG8C
• DSSTox Substance ID: DTXSID60150176
• Nikkaji Number: J203.370D
• Wikidata: Q83016149
• Mol file: 1128-32-1.mol

Synonyms:2,3-dimethoxy-5-methylphenol;1128-32-1;4,5-Dimethoxy-3-hydroxytoluene;5,6-Dimethoxy-m-cresol;Phenol,2,3-dimethoxy-5-methyl-;EINECS 214-437-1;T26EB3VG8C;UNII-T26EB3VG8C;SCHEMBL1427958;DTXSID60150176;MFCD00017288;AKOS006281045;FT-0691387;6-METHOXY-BENZO[B]THIOPHENE-2-CARBOXYLICACID

Chemical Property of 2,3-Dimethoxy-5-methylphenol

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 270.9°Cat760mmHg
• Flash Point: 117.6°C
• PSA: 38.69000
• Density: 1.105g/cm³
• LogP: 1.71780
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 138

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3-Dimethoxy-5-methylphenol AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)OC)OC)O

Technology Process of 2,3-Dimethoxy-5-methylphenol

There total 22 articles about 2,3-Dimethoxy-5-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-benzyloxy-4,5-dimethoxytoluene (152898-30-1) → 2,3-dimethoxy-5-methylphenol (1128-32-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1055/s-1993-25945

Reference yield: 95.0%

3-benzyloxy-4,5-dimethoxybenzyl alcohol (7632-62-4) → 2,3-dimethoxy-5-methylphenol (1128-32-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; atmospheric pressure;

DOI:10.1248/cpb.51.794

Reference yield: 68.2%

5-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)valeric acid (58185-80-1) → 2,3-dimethoxy-5-methylphenol (1128-32-1)

Guidance literature:

With hydrogenchloride; mercury dichloride; In water; toluene; for 13h; Heating; other reagents: HCl alone, HgCl₂ alone;

DOI:10.1248/cpb.30.2797

upstream raw materials:

(3-hydroxy-4,5-dimethoxy-phenyl)-acetic acid

5-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)valeric acid

3-benzyloxy-4,5-dimethoxytoluene

3-benzyloxy-4,5-dimethoxybenzyl alcohol

Downstream raw materials:

3-(5,6-Dimethoxy-3-methyl-phenoxy)-butanon-⁽²⁾

2-[3-(2,3-dimethoxy-5-methyl-phenoxy)-4,5-dimethoxy-benzyloxy]-tetrahydro-pyran

2-[(E)-3,7-dimethyl-2,6-octadienyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone

violacerol-II