3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine
• CAS No.: 170790-19-9
• Molecular Formula: C₂₈H₂₉F₂N₃O₂
• Molecular Weight: 477.554
• Mol file: 170790-19-9.mol

Synonyms:3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

Chemical Property of 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine

There total 7 articles about 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(2,4-Difluoro-phenyl)-3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-acrylic acid ethyl ester (170790-14-4) → 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine (170790-19-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm9508853

Reference yield:

2,4-difluorobenzonitrile (3939-09-1,103496-86-2) → 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine (170790-19-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) magnesium, 3.) 1N aq. HCl

2: 1.) NaH / 1.) dimethoxyethane, RT, 30 min, 2.) dimethoxyethane, reflux, 4 d

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) 50percent NaH / 1.) DMF, 15 min, 2.) DMF, RT, overnight

5: H₂ / Pd/C / ethanol

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; hydrogen; sodium hydride; magnesium; palladium on activated charcoal; In tetrachloromethane; ethanol;

DOI:10.1021/jm9508853

Reference yield:

para-bromotoluene (106-38-7) → 3-[[4-[1-(2,4-Difluorophenyl)-2-ethoxycarbonylethyl]phenyl]methyl]-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine (170790-19-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) magnesium, 3.) 1N aq. HCl

2: 1.) NaH / 1.) dimethoxyethane, RT, 30 min, 2.) dimethoxyethane, reflux, 4 d

3: N-bromosuccinimide, benzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) 50percent NaH / 1.) DMF, 15 min, 2.) DMF, RT, overnight

5: H₂ / Pd/C / ethanol

With hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; hydrogen; sodium hydride; magnesium; palladium on activated charcoal; In tetrachloromethane; ethanol;

DOI:10.1021/jm9508853

upstream raw materials:

(E)-3-(2,4-Difluoro-phenyl)-3-[4-(2-ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenyl]-acrylic acid ethyl ester

para-bromotoluene

2,4-difluorobenzonitrile

(2,4-Difluoro-phenyl)-p-tolyl-methanone