N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

Base Information

Chemical Name:N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine
CAS No.:1345219-57-9
Molecular Formula:C₂₄H₃₀N₂O₅
Molecular Weight:426.513
Hs Code.:

Synonyms:N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

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Chemical Property of N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

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Technology Process of N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

There total 2 articles about N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1345219-51-3
N-[1-(S)-benzyloxycarbonyl-3-phenylpropyl]-L-4,4'-biphenylalanyl-α-(S)-methyl-β-alanine benzyl ester

: 1345219-57-9
N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; water; acetic acid; at 20 ℃; for 37.5h;
DOI:10.1016/j.bmc.2011.08.064

Reference yield:

: 1345219-44-4
L-4,4'-biphenylalanyl-α-(S)-methyl-β-alanine benzyl ester formate

: 1345219-57-9
N-[1-(S)-carboxy-3-phenylpropyl]-L-4-methylphenylalanyl-α-(S)-methyl-β-alanine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere

1.2: 72 h / -78 - 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol; water; acetic acid / 37.5 h / 20 °C

With trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; water; acetic acid;
DOI:10.1016/j.bmc.2011.08.064