(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

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Chemical Name:(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione
CAS No.:1397683-42-9
Molecular Formula:C₁₈H₁₅ClN₄S
Molecular Weight:354.863
Hs Code.:

Synonyms:(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

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Chemical Property of (R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

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Technology Process of (R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

There total 12 articles about (R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1397683-41-8
(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

: 1397683-42-9
(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

Guidance literature:: With tetraphosphorus decasulfide; In pyridine; at 100 ℃; for 5h;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1397683-42-9
(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

Guidance literature:: Multi-step reaction with 11 steps

1.1: hydrogenchloride / 96 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

2.2: 20 °C

3.1: Chiralpak_.(R). Daicel AD / carbon dioxide; isopropylamine; methanol

4.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

4.2: pH 1 - 2 / Cooling with ice

5.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

5.2: 64 h / 20 °C

6.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

7.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

7.2: 2 h

8.1: dichloromethane / 2 h / 0 - 20 °C

9.1: potassium carbonate / ethanol / 5 h / 20 - 90 °C

10.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

11.1: tetraphosphorus decasulfide / pyridine / 5 h / 100 °C

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; tetraphosphorus decasulfide; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; caesium carbonate; ruthenium trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; isopropylamine; acetonitrile;

Reference yield:

: 1183581-39-6
(RS)-2-amino-2-(3-bromo-phenyl)-propionic acid methyl ester

: 1397683-42-9
(R)-6-[3-(5-chloro-pyridin-3-yl)-phenyl]-6-methyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazine-4-thione

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

1.2: 20 °C

2.1: Chiralpak_.(R). Daicel AD / carbon dioxide; isopropylamine; methanol

3.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

3.2: pH 1 - 2 / Cooling with ice

4.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

4.2: 64 h / 20 °C

5.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

6.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

6.2: 2 h

7.1: dichloromethane / 2 h / 0 - 20 °C

8.1: potassium carbonate / ethanol / 5 h / 20 - 90 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Inert atmosphere; Microwave irradiation

10.1: tetraphosphorus decasulfide / pyridine / 5 h / 100 °C

With sodium periodate; lithium aluminium tetrahydride; thionyl chloride; tetraphosphorus decasulfide; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; caesium carbonate; ruthenium trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; isopropylamine; acetonitrile;