3-(2-methoxy-phenyl)-trans-crotonic acid

Base Information

• Chemical Name: 3-(2-methoxy-phenyl)-trans-crotonic acid
• CAS No.: 133572-07-3
• Molecular Formula: C₁₁H₁₂O₃
• Molecular Weight: 192.214
• Mol file: 133572-07-3.mol

Synonyms:3-(2-methoxy-phenyl)-trans-crotonic acid

Chemical Property of 3-(2-methoxy-phenyl)-trans-crotonic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-methoxy-phenyl)-trans-crotonic acid

There total 4 articles about 3-(2-methoxy-phenyl)-trans-crotonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(2-methoxyphenyl)but-2-enal → 3-(2-methoxy-phenyl)-trans-crotonic acid (133572-07-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; Phenazin; BF₄^(1-)*C₂₁H₂₂N₃O⁽¹⁺⁾; water-d2; In acetonitrile; at 40 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.0c00636

Reference yield:

2-Methoxyacetophenone (579-74-8) → 3-(2-methoxy-phenyl)-trans-crotonic acid (133572-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 12 h / 0 - 20 °C

2: sodium hydroxide / 2 h / Reflux

With sodium hydride; sodium hydroxide; In tetrahydrofuran; mineral oil;

DOI:10.1002/cjoc.201600929

Reference yield:

3-(2-methoxy-phenyl)-crotonic acid ethyl ester (7706-84-5) → 3-(2-methoxy-phenyl)-trans-crotonic acid (133572-07-3)

Guidance literature:

Reaktion ueber mehrere Stufen;

upstream raw materials:

3-(2-methoxy-phenyl)-crotonic acid ethyl ester

2-Methoxyacetophenone

Downstream raw materials:

C₁₀H₁₀Br₂O