Technology Process of (2S,4S)-4-Benzyloxy-2-methyl-5-triethylsilanyloxy-pentanal
There total 10 articles about (2S,4S)-4-Benzyloxy-2-methyl-5-triethylsilanyloxy-pentanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
molecular sieve; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol026034o
- Guidance literature:
-
Multi-step reaction with 9 steps
1: AD mix α; sodium hydrogen carbonate / 2-methyl-propan-2-ol; H2O / 22.5 h / 0 - 5 °C
2: 42 percent / 2,6-lutidine / CH2Cl2 / 0.25 h / -78 °C
3: 99 percent / lithium borohydride / methanol; tetrahydrofuran / 4 h / 0 °C
4: 66 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2
5: sodium hydride / dimethylformamide / -50 - -10 °C
6: 340 mg / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h
7: 95 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 0.75 h / 0 °C
8: 99 percent / lithium borohydride; ammonium chloride / H2O; tetrahydrofuran / 2.5 h / 0 - 20 °C
9: 87 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves / CH2Cl2 / 0.5 h / 20 °C
With
2,6-dimethylpyridine; dmap; AD-mix-α; lithium borohydride; molecular sieve; tetrapropylammonium perruthennate; ammonium chloride; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol026034o
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 99 percent / n-BuLi / tetrahydrofuran; hexane / 0.58 h
2: AD mix α; sodium hydrogen carbonate / 2-methyl-propan-2-ol; H2O / 22.5 h / 0 - 5 °C
3: 42 percent / 2,6-lutidine / CH2Cl2 / 0.25 h / -78 °C
4: 99 percent / lithium borohydride / methanol; tetrahydrofuran / 4 h / 0 °C
5: 66 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2
6: sodium hydride / dimethylformamide / -50 - -10 °C
7: 340 mg / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h
8: 95 percent / 4-(dimethylamino)pyridine; Et3N / CH2Cl2 / 0.75 h / 0 °C
9: 99 percent / lithium borohydride; ammonium chloride / H2O; tetrahydrofuran / 2.5 h / 0 - 20 °C
10: 87 percent / tetrapropylammonium perruthenate; 4-methylmorpholine N-oxide; molecular sieves / CH2Cl2 / 0.5 h / 20 °C
With
2,6-dimethylpyridine; dmap; AD-mix-α; lithium borohydride; n-butyllithium; molecular sieve; tetrapropylammonium perruthennate; ammonium chloride; tetrabutyl ammonium fluoride; sodium hydride; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; triethylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol026034o
