N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Base Information

• Chemical Name: N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine
• CAS No.: 1190115-61-7
• Molecular Formula: C₃₀H₃₈N₆O₃S
• Molecular Weight: 562.736
• Mol file: 1190115-61-7.mol

Synonyms:N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Chemical Property of N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

There total 2 articles about N₅-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₇-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-amino-2-(isopropylsulphonyl)benzene (76697-50-2) + 5,7-dichloropyrazolo[1,5-a]pyrimidine (57489-77-7) → N5-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N7-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine (1190115-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride; N,N-dimethyl-formamide / 2 h / 50 °C

2: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 3 h / 150 °C

With hydrogenchloride; sodium hydride; N,N-dimethyl-formamide; In 1,4-dioxane; isopropyl alcohol;

Reference yield:

5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (1035230-24-0) + 5-chloro-N-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a] pyrimidin-7-amine (1190115-62-8) → N5-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N7-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine (1190115-61-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 150 ℃; for 3h;

upstream raw materials:

5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine

5-chloro-N-(2-(isopropylsulfonyl)phenyl)pyrazolo[1,5-a] pyrimidin-7-amine

1-amino-2-(isopropylsulphonyl)benzene

5,7-dichloropyrazolo[1,5-a]pyrimidine