(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Base Information

Chemical Name:(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene
CAS No.:170707-23-0
Molecular Formula:C₄₁H₆₄O₇Si₂
Molecular Weight:725.126
Hs Code.:

(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Synonyms:(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Suppliers and Price of (4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

There total 8 articles about (4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 170707-22-9
(4aR,5aS,6aR,8R,10S,10aS,11aR,12aS)-8-[3-(tert-Butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacen-10-ol

: 170707-23-0
(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/ja00099a081 DOI:10.1021/ja00146a010

Reference yield:

: 122822-08-6
2,6:5,9:8,12-Trianhydro-4-O-benzyl-1-O-(tert-butyldiphenylsilyl)-3,7,10-trideoxy-5-C-methyl-D-allo-D-altro-tridecitol

: 170707-23-0
(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / CSA / CH₂Cl₂ / 4 h / 0 °C

2: 97 percent / TBAF / tetrahydrofuran / 2 h / 25 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) CH₂Cl₂

4: 96 percent / CH₂Cl₂ / 5 h / 25 °C

5: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 48 h / 25 °C

6: 92 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

7: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 6 h / 25 °C

8: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

With 2,6-dimethylpyridine; dmap; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00146a010

Reference yield:

: 170707-21-8
((4aR,5aS,6aR,8S,10S,10aS,11aR,12aS)-10-Benzyloxy-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacen-8-yl)-methanol

: 170707-23-0
(4aR,5aS,6aR,8R,10S,10aR,11aR,12aS)-10-(tert-Butyl-dimethyl-silanyloxy)-8-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-2,2,10a-trimethyl-dodecahydro-1,3,5,7,11-pentaoxa-naphthacene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 0.5 h, 2.) CH₂Cl₂

2: 96 percent / CH₂Cl₂ / 5 h / 25 °C

3: 100 percent / H₂ / Pd(OH)2 / ethyl acetate / 48 h / 25 °C

4: 92 percent / LiAlH₄ / tetrahydrofuran / 0.25 h / 0 °C

5: 93 percent / Et₃N, DMAP / CH₂Cl₂ / 6 h / 25 °C

6: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

With 2,6-dimethylpyridine; dmap; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00146a010