(-)-englerin A

Base Information

• Chemical Name: (-)-englerin A
• CAS No.: 1094250-15-3
• Molecular Formula: C₂₆H₃₄O₆
• Molecular Weight: 442.552
• Mol file: 1094250-15-3.mol

Synonyms:(-)-englerin A

Chemical Property of (-)-englerin A

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

EnglerinA ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Englerin A is a selective inhibitor of renal cancer cell growth.

Technology Process of (-)-englerin A

There total 99 articles about (-)-englerin A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,3aR,4S,5R,7R,8S,8aR)-5-(2-((tert-butyldiphenylsilyl)oxy)acetoxy)-7-isopropyl-1,4-dimethyldecahydro-4,7-epoxyazulen-8-yl cinnamate (1232773-30-6) → (-)-englerin A (1094250-15-3)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 23 ℃; for 1.5h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.9b12940

Reference yield: 100.0%

C32H48O6Si → (-)-englerin A (1094250-15-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 0.5h; Inert atmosphere;

DOI:10.1002/anie.201301247

Reference yield: 100.0%

C34H42O7 → (-)-englerin A (1094250-15-3)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 - 23 ℃; for 7h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201607348

upstream raw materials:

3-methyl-butan-2-one

C₁₅H₂₄O₃

cesium hydroxyacetate

C₂₇H₃₄N₂O₆S

Downstream raw materials:

(-)-englerin B

2',3'-dichlorodihydroenglerin A