(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide
CAS No.:1429291-96-2
Molecular Formula:C₂₁H₁₈Cl₂F₂N₂O₃
Molecular Weight:455.288
Hs Code.:

Synonyms:(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Chemical Property of (R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

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Technology Process of (R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

There total 6 articles about (R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1429293-48-0
(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-ethoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

: 1429291-96-2
(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: With boron trichloride; In chloroform; at 20 ℃; for 14h;

Reference yield:

: 1429293-27-5
dimethyl 1-(2,4-difluorophenyl)-4-ethoxy-5-oxo-2,5-dihydro-1H-pyrrole-2,3-dicarboxylate

: 1429291-96-2
(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide; methanol / tetrahydrofuran / 0.5 h / Reflux

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1.5 h / 20 °C

3: triethylamine / dichloromethane / 14 h / 20 °C

4: boron trichloride / chloroform / 14 h / 20 °C

With methanol; oxalyl dichloride; boron trichloride; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; chloroform;

Reference yield:

: 1429293-26-4
1-(2,4-difluorophenyl)-4-ethoxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid

: 1429291-96-2
(R)-N-(4-(3,4-dichlorophenyl)butan-2-yl)-1-(2,4-difluorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1.5 h / 20 °C

2: triethylamine / dichloromethane / 14 h / 20 °C

3: boron trichloride / chloroform / 14 h / 20 °C

With oxalyl dichloride; boron trichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane; chloroform;