(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

Base Information

Chemical Name:(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester
CAS No.:133550-28-4
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

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Chemical Property of (Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

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Technology Process of (Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

There total 1 articles about (Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1116-98-9
cyanoacetic acid tert-butyl ester

: 938-18-1
mesitylene-2-carboxylic acid chloride

: 133550-28-4
(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) ether, 20 min, 2.) ether, RT, 3 h;
DOI:10.1021/jm00110a022

Reference yield: 81.0%

: 133550-28-4
(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

: 116283-33-1
3-mesityl-3-oxo-propionitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3.5h; Ambient temperature;
DOI:10.1021/jm00110a022

Reference yield:

: 133550-28-4
(Z)-2-Cyano-3-hydroxy-3-(2,4,6-trimethyl-phenyl)-acrylic acid tert-butyl ester

: 133550-29-5
(E)-3-(3,4-Dihydroxy-phenyl)-2-(2,4,6-trimethyl-benzoyl)-acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / TFA / CH₂Cl₂ / 3.5 h / Ambient temperature

2: 37 percent

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00110a022