[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

Base Information

Chemical Name:[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid
CAS No.:1529807-55-3
Molecular Formula:C₂₀H₂₃BCl₂N₂O₉
Molecular Weight:519.117
Hs Code.:

[<sup>14</sup>C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

Synonyms:[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

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Chemical Property of [¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

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Technology Process of [¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

There total 5 articles about [¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1529807-54-2
[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

: 77-92-9,906507-37-7
citric acid

: 1529807-55-3
[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

Guidance literature:: In ethyl acetate; at 60 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1002/jlcr.3079

Reference yield:

: 1529807-51-9
[¹⁴C]-methyl-[(2,5-dichlorobenzoyl)amino]acetate

: 1529807-55-3
[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide; water / methanol / 20 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

3.1: Dihydroxy-isobutyl-boran; hydrogenchloride; water / methanol; hexane / 4 h / 20 °C / Inert atmosphere

4.1: ethyl acetate / 0.17 h / 60 °C / Inert atmosphere

With hydrogenchloride; Dihydroxy-isobutyl-boran; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; lithium hydroxide; In methanol; hexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.3079

Reference yield:

: 1529807-52-0
[¹⁴C]-[(2,5-dichlorobenzoyl)amino]acetic acid

: 1529807-55-3
[¹⁴C]-(R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: Dihydroxy-isobutyl-boran; hydrogenchloride; water / methanol; hexane / 4 h / 20 °C / Inert atmosphere

3.1: ethyl acetate / 0.17 h / 60 °C / Inert atmosphere

With hydrogenchloride; Dihydroxy-isobutyl-boran; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In methanol; hexane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/jlcr.3079