benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine

Base Information

• Chemical Name: benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine
• CAS No.: 271600-77-2
• Molecular Formula: C₆₇H₇₄N₈O₁₅
• Molecular Weight: 1231.37
• Mol file: 271600-77-2.mol

Synonyms:benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine

Chemical Property of benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine

There total 8 articles about benzyl ester of N^α,N^G,N^G-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Val-ONSu (3392-12-9) → benzyl ester of Nα,NG,NG-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine (271600-77-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 77 percent / Et₃N / dimethylformamide / 24 h / 20 °C

2: TFA / CH₂Cl₂ / 1 h / 20 °C

3: N-ethylmorpholine / dimethylformamide / 24 h / 20 °C

4: 36 percent / TFA / CH₂Cl₂ / 49 h / 0 - 20 °C

5: N-ethylmorpholine; DPPA / dimethylformamide

With N-ethylmorpholine;; diphenyl-phosphinic acid; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrolysis / 5: Condensation;

Reference yield:

H-Val-Tyr-OBzl (80621-99-4) → benzyl ester of Nα,NG,NG-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine (271600-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethylmorpholine / dimethylformamide / 24 h / 20 °C

2: 36 percent / TFA / CH₂Cl₂ / 49 h / 0 - 20 °C

3: N-ethylmorpholine; DPPA / dimethylformamide

With N-ethylmorpholine;; diphenyl-phosphinic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrolysis / 3: Condensation;

Reference yield:

Nα,NG,NG-tri-Z-arginine p-nitrophenylester (14611-35-9) → benzyl ester of Nα,NG,NG-tribenzyloxycarbonyl-argynyl-N-prolyl-β-benzylaspartyl-valyl-tyrosine (271600-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent

2: N-ethylmorpholine; DPPA / dimethylformamide

With N-ethylmorpholine;; diphenyl-phosphinic acid; In N,N-dimethyl-formamide; 1: Condensation / 2: Condensation;

upstream raw materials:

H-Asp(OBzl)-Val-Tyr-OBzl

tris(benzyloxycarbonyl)-L-arginyl-L-proline

Boc-Val-ONSu

H-Val-Tyr-OBzl

Downstream raw materials:

2>-thymopentin (Arg-Pro-Asp-Val-Tyr)