2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

Base Information

Chemical Name:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole
CAS No.:1521139-25-2
Molecular Formula:C₂₄H₁₉FN₄O₂
Molecular Weight:414.439
Hs Code.:

Synonyms:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

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Chemical Property of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

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Technology Process of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

There total 8 articles about 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.1%

: 41014-43-1
2-(chloromethyl)benzoxazole

: 1301167-65-6
4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol

: 1521139-25-2
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 171001-06-2
1-(4-(benzyloxy)phenyl)-2-(pyridin-4-yl)ethanone

: 1521139-25-2
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 1 h / Reflux

1.2: 2 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

4.1: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 18 h / 1900.13 Torr / Autoclave

5.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1521138-31-7
2-(3-(4-(benzyloxy)phenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl)ethyl methanesulfonate

: 1521139-25-2
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)benzo[d]oxazole

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 18 h / 1900.13 Torr / Autoclave

3: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;