N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph

Base Information

• Chemical Name: N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph
• CAS No.: 911675-46-2
• Molecular Formula: C₆₁H₆₆N₈O₁₀
• Molecular Weight: 1071.24
• Mol file: 911675-46-2.mol

Synonyms:N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph

Chemical Property of N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph

There total 7 articles about N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH₂Ph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-Boc-Tyr(Bn)-Arg(Z)2-OH (911675-28-0) + (S)-2-amino-N-benzyl-3-(1H-indole-3-yl)propanamide (125009-81-6) → N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH2Ph (911675-46-2)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0701324

Reference yield: 49.0%

→ N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH2Ph (911675-46-2)

Guidance literature:

Reference yield:

Z-Trp-NHCH2Ph (158951-60-1) → N-Boc-Tyr(Bn)-Arg(Z)2-Trp-NHCH2Ph (911675-46-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / H₂ / Pd/C / methanol; dimethylformamide

2: 49 percent / EDC; HOBt; NEt₃ / CH₂Cl₂; dimethylformamide

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0701324

upstream raw materials:

N-Boc-Tyr(Bn)-Arg(Z)2-OH

(S)-2-amino-N-benzyl-3-(1H-indole-3-yl)propanamide

Z-Trp-NHCH₂Ph

t-butyloxycarbonyl-O-benzyl-L-tyrosine hydroxysuccinimide ester

Refernces

• 1、 -. "COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY". Page/Page column 59. . Retrieved 2008/06/13.