3-Methoxy-4-hydroxyclomiphene

Base Information

Chemical Name:3-Methoxy-4-hydroxyclomiphene
CAS No.:117095-59-7
Molecular Formula:C27H30 Cl N O3
Molecular Weight:451.98
Hs Code.:
DSSTox Substance ID:DTXSID301017065
ChEMBL ID:CHEMBL955
Mol file:117095-59-7.mol

Synonyms:1-(4-(2-(diethylamino)ethoxy)phenyl)-1-(3-methoxy-4-hydroxyphenyl)-2-phenyl-2-chloroethane;3-methoxy-4-hydroxyclomiphene

Suppliers and Price of 3-Methoxy-4-hydroxyclomiphene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 23 raw suppliers

Chemical Property of 3-Methoxy-4-hydroxyclomiphene

Chemical Property:

Vapor Pressure:2.67E-13mmHg at 25°C
Melting Point:96-98 °C
Boiling Point:563.4°Cat760mmHg
PKA:8.42±0.20(Predicted)
Flash Point:294.5°C
PSA：41.93000
Density:1.158g/cm³
LogP:6.27680
XLogP3:6.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:451.1914215
Heavy Atom Count:32
Complexity:565

Purity/Quality:: 99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC(=C(C=C3)O)OC
Isomeric SMILES:CCN(CC)CCOC1=CC=C(C=C1)/C(=C(\C2=CC=CC=C2)/Cl)/C3=CC(=C(C=C3)O)OC

Technology Process of 3-Methoxy-4-hydroxyclomiphene

There total 6 articles about 3-Methoxy-4-hydroxyclomiphene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid 4-{(Z)-2-chloro-1-[4-(2-diethylamino-ethoxy)-phenyl]-2-phenyl-vinyl}-2-methoxy-phenyl ester

: 117095-59-7
1-<4-<2-(diethylamino)ethoxy>phenyl>-1-(3-methoxy-4-hydroxyphenyl)-2-phenyl-2-chloroethene

Guidance literature:: With hydrogenchloride; In methanol; at 70 ℃; for 0.166667h; Yield given;
DOI:10.1021/jm00121a035

Reference yield:

: 4421-08-3
3-methoxy-4-hydroxybenzonitrile

: 117095-59-7
1-<4-<2-(diethylamino)ethoxy>phenyl>-1-(3-methoxy-4-hydroxyphenyl)-2-phenyl-2-chloroethene

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / 1) NaH / 1) THF, 0 deg C, 2) THF, r.t., 16 h

2: 20 percent / tetrahydrofuran / 5 h / Heating

3: 2) aq. HCl / 1) ether, 2 h 2) r.t., 48 h

4: 6 h / Ambient temperature

5: N-chlorosuccinimide / 24 h / Heating

6: 10percent aq. HCl / methanol / 0.17 h / 70 °C

With hydrogenchloride; N-chloro-succinimide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00121a035

Reference yield:

: 117095-56-4
1-<(2-methoxyethoxy)methoxy>-2-methoxy-4-cyanobenzene

: 117095-59-7
1-<4-<2-(diethylamino)ethoxy>phenyl>-1-(3-methoxy-4-hydroxyphenyl)-2-phenyl-2-chloroethene

Guidance literature:: Multi-step reaction with 5 steps

1: 20 percent / tetrahydrofuran / 5 h / Heating

2: 2) aq. HCl / 1) ether, 2 h 2) r.t., 48 h

3: 6 h / Ambient temperature

4: N-chlorosuccinimide / 24 h / Heating

5: 10percent aq. HCl / methanol / 0.17 h / 70 °C

With hydrogenchloride; N-chloro-succinimide; In tetrahydrofuran; methanol;
DOI:10.1021/jm00121a035