1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea

Base Information

Chemical Name:1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea
CAS No.:882672-42-6
Molecular Formula:C₁₄H₁₉F₃N₄O₂
Molecular Weight:332.326
Hs Code.:
DSSTox Substance ID:DTXSID601158177

Synonyms:1-(2-amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea;882672-42-6;SCHEMBL5492780;DTXSID601158177

Suppliers and Price of 1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:332.14601035
Heavy Atom Count:23
Complexity:389

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1CCNC(=O)NC2=C(C=C(C=C2)C(F)(F)F)N

Technology Process of 1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea

There total 3 articles about 1-(2-Amino-4-(trifluoromethyl)phenyl)-3-(2-morpholinoethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882679-51-8
1-(2-morpholin-4-ylethyl)-3-(2-nitro-4-(trifluoromethyl)phenyl)urea

: 882672-42-6
1-(2-amino-4-(trifluoromethyl)phenyl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 24h;
DOI:10.1021/jm0605482

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 882672-42-6
1-(2-amino-4-(trifluoromethyl)phenyl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 16 h / 40 °C

2: 0.650 g / H₂ / Pd/C / methanol; ethyl acetate / 24 h

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; benzene;
DOI:10.1021/jm0605482

Reference yield:

: 16588-70-8
2-nitro-4-(trifluoromethyl)phenylisocyanate

: 882672-42-6
1-(2-amino-4-(trifluoromethyl)phenyl)-3-(2-morpholin-4-ylethyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 16 h / 40 °C

2: 0.650 g / H₂ / Pd/C / methanol; ethyl acetate / 24 h

With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; benzene;
DOI:10.1021/jm0605482