(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Base Information

Chemical Name:(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone
CAS No.:214210-35-2
Molecular Formula:C₁₇H₂₆O₂Si
Molecular Weight:290.478
Hs Code.:

Synonyms:(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Suppliers and Price of (3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

There total 12 articles about (3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 768-33-2
phenyldimethylsilyl chloride

: 98587-10-1
(S)-3-n-butyl-5-methylfuran-2(5H)-one

: 214210-35-2
(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Guidance literature:: phenyldimethylsilyl chloride; With lithium doped with sodium; In tetrahydrofuran; at 0 ℃; for 16h; Inert atmosphere;

With copper(l) cyanide; In tetrahydrofuran; at -70 - 0 ℃; for 0.333333h; Inert atmosphere;

(S)-3-n-butyl-5-methylfuran-2(5H)-one; Further stages;
DOI:10.1016/j.tet.2012.07.088

Reference yield: 84.0%

: 110769-32-9
(PhMe₂Si)2CuCNLi₂

: 98587-10-1
(S)-3-n-butyl-5-methylfuran-2(5H)-one

: 214210-35-2
(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Guidance literature:: (PhMe₂Si)2CuCNLi₂; (S)-3-n-butyl-5-methylfuran-2(5H)-one; at 70 ℃;

diastereoselective reaction; Acidic conditions;
DOI:10.1016/j.tetlet.2010.10.089

Reference yield: 73.0%

: 542-69-8
1-iodo-butane

: (4R,5S)-4-<(dimethylphenyl)silyl>-4,5-dihydro-5-methyl-2(3H)-furanone

: 214210-35-2
(3S,4R,5S)-3-butyl-4-(dimethylphenylsilyl)-4,5-dihydro-5-methyl-2(3H)-furanone

Guidance literature:: (4R,5S)-4-<(dimethylphenyl)silyl>-4,5-dihydro-5-methyl-2(3H)-furanone; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.5h; Inert atmosphere;

1-iodo-butane; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c3cc42160k