2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

Base Information

Chemical Name:2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione
CAS No.:681482-57-5
Molecular Formula:C₂₁H₂₀F₃N₃O₂
Molecular Weight:403.404
Hs Code.:

Synonyms:2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

Chemical Property:

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Technology Process of 2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

There total 1 articles about 2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 574-98-1
2-(2-bromoethyl)isoindoline-1,3-dione

: 30459-17-7
1-[4-(trifluoromethyl)phenyl]piperazine

: 681482-57-5
2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;
DOI:10.1002/cmdc.201300474

Reference yield:

: 681482-57-5
2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

: 681482-58-6
C₁₃H₁₈F₃N₃

Guidance literature:: With hydrazine hydrate; In ethanol; Reflux;
DOI:10.1016/j.bmcl.2010.05.030

Reference yield:

: 681482-57-5
2-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

: 1608157-03-4
N⁵-(2-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazine-5,7-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 70 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C

2.2: Reflux

With hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;
DOI:10.1002/cmdc.201300474