ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

Base Information

Chemical Name:ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate
CAS No.:119915-67-2
Molecular Formula:C₁₅H₁₄ClF₃O₄
Molecular Weight:350.722
Hs Code.:

Synonyms:ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

Chemical Property:

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Technology Process of ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

There total 9 articles about ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 119915-66-1
ethyl 3-chloro-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

: 122-51-0
orthoformic acid triethyl ester

: 119915-67-2
ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

Guidance literature:: With acetic anhydride; Heating;
DOI:10.1002/jhet.5570270616

Reference yield:

: 446-17-3
2,4,5-trifluorobenzoic acid

: 119915-67-2
ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 9 steps

1: COCl₂, DMF / CH₂Cl₂ / Ambient temperature

2: CH₂Cl₂ / Ambient temperature

3: SOCl₂ / CHCl₃ / Ambient temperature

4: 1) lithium diisopropylamide, 2) hexachloroacetone / 1) THF, -78 deg C, 2) up to room temp.

5: 1) lithium diisopropylamide / 1) THF, 0 deg C, 2) up to room temp.

6: 62 percent / 6 N HCl / Heating

7: COCl₂, DMF / CH₂Cl₂ / Ambient temperature

8: 1) n-BuLi, bipyridyl / 1) THF, -35 -> -5 deg C, 2) THF, -78 deg C

9: 97 percent / acetic anhydride / Heating

With hydrogenchloride; [2,2]bipyridinyl; n-butyllithium; thionyl chloride; 1,1,1,3,3,3-hexachloro-propan-2-one; acetic anhydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In dichloromethane; chloroform;
DOI:10.1002/jhet.5570270616

Reference yield:

: 88419-56-1
2,4,5-trifluorobenzoyl chloride

: 119915-67-2
ethyl 3-chloro-α-(ethoxymethylene)-2,4,5-trifluoro-6-methyl-β-oxobenzenepropanoate

Guidance literature:: Multi-step reaction with 8 steps

1: CH₂Cl₂ / Ambient temperature

2: SOCl₂ / CHCl₃ / Ambient temperature

3: 1) lithium diisopropylamide, 2) hexachloroacetone / 1) THF, -78 deg C, 2) up to room temp.

4: 1) lithium diisopropylamide / 1) THF, 0 deg C, 2) up to room temp.

5: 62 percent / 6 N HCl / Heating

6: COCl₂, DMF / CH₂Cl₂ / Ambient temperature

7: 1) n-BuLi, bipyridyl / 1) THF, -35 -> -5 deg C, 2) THF, -78 deg C

8: 97 percent / acetic anhydride / Heating

With hydrogenchloride; [2,2]bipyridinyl; n-butyllithium; thionyl chloride; 1,1,1,3,3,3-hexachloro-propan-2-one; acetic anhydride; N,N-dimethyl-formamide; lithium diisopropyl amide; In dichloromethane; chloroform;
DOI:10.1002/jhet.5570270616