1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453853-44-5
Molecular Formula:C₂₀H₁₄ClFN₄O₄S
Molecular Weight:460.873
Hs Code.:

Synonyms:1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of 1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of 1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

There total 8 articles about 1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1453853-42-3
1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453853-44-5
1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1453853-38-7
(4-chloro-3-fluorophenyl)(oxazol-5-yl)methanol

: 1453853-44-5
1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hydride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1453853-40-1
5-(chloro(4-chloro-3-fluorophenyl)methyl)oxazole

: 1453853-44-5
1-((4-chloro-3-fluorophenyl)(oxazol-5-yl)methyl)-4-(2-(methyl sulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Inert atmosphere

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;