2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione

Base Information

• Chemical Name: 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione
• CAS No.: 909782-88-3
• Molecular Formula: C₃₇H₃₅N₃O₉
• Molecular Weight: 665.7

Synonyms:2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione

Chemical Property of 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione

Chemical Property:

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Technology Process of 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione

There total 6 articles about 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-(2-deoxy-β-D-erythro-pentofuranosyl)-N4-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione (909782-86-1) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N4-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione (909782-88-3)

Guidance literature:

In pyridine; at 20 ℃;

DOI:10.1021/jo0702903

Reference yield:

2-(2-deoxy-β-D-erythro-pentofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione (10592-61-7,20500-29-2,54918-16-0,93060-33-4) → 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N4-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione (909782-88-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 1 h / 20 °C

2: pyridine / 3 h / 20 °C

3: 0.65 g / trifluoroacetic acid / CH₂Cl₂; methanol / 1 h / 20 °C

4: 62 percent / pyridine / 20 °C

With trifluoroacetic acid; In pyridine; methanol; dichloromethane;

DOI:10.1021/jo0702903

Reference yield:

C20H39O5N3Si2 → 2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N4-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione (909782-88-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 3 h / 20 °C

2: 0.65 g / trifluoroacetic acid / CH₂Cl₂; methanol / 1 h / 20 °C

3: 62 percent / pyridine / 20 °C

With trifluoroacetic acid; In pyridine; methanol; dichloromethane;

DOI:10.1021/jo0702903

upstream raw materials:

2-(2-deoxy-β-D-erythro-pentofuranosyl)-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)dione

4,4'-dimethoxytrityl chloride

2-(2-deoxy-β-D-erythro-pentofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione

2-[2-deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl]-1,2,4-triazine-3,5(2H,4H)-dione

Downstream raw materials:

2-[2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]-N⁴-(2-methoxybenzoyl)-1,2,4-triazin-3,5(2H,4H)-dione 3'-(2-cyanoethyl diisopropylphosphoramidite)

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