5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

Base Information

Chemical Name:5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol
CAS No.:900509-61-7
Molecular Formula:C₂₆H₃₈O₈
Molecular Weight:478.583
Hs Code.:

Synonyms:5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

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Chemical Property of 5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

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Technology Process of 5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

There total 11 articles about 5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 900509-60-6
5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pent-1-yn-3-ol

: 900509-61-7
5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

Guidance literature:: With hydrogen; potassium carbonate; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 900509-52-6
1-iodo-2-((2-methoxyethoxy)methoxy)benzene

: 900509-61-7
5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / Ph₃P; Et₃N; CuI / PdCl₂(PPh₃)2 / 80 °C

2.1: 86 percent / NaOH / toluene / 3.5 h / Heating

3.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

3.2: 51 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 77 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

With sodium hydroxide; copper(l) iodide; n-butyllithium; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate; toluene; 1.1: Sonogashira coupling;
DOI:10.1016/j.tet.2006.04.026

Reference yield:

: 900509-54-8
1-ethynyl-2-((2-methoxyethoxy)methoxy)benzene

: 900509-61-7
5-[(3-methoxy)-2-((2-methoxyethoxy)methoxy)phenyl]-1-[2-((2-methoxyethoxy)methox)phenyl]-pentan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.67 h / -78 °C

1.2: 51 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: 77 percent / H₂; K₂CO₃ / Pd/C / ethyl acetate / 2 h / 20 °C

With n-butyllithium; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; hexane; ethyl acetate;
DOI:10.1016/j.tet.2006.04.026