methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Base Information

Chemical Name:methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate
CAS No.:367260-30-8
Molecular Formula:C₂₇H₂₆Cl₂N₂O₃
Molecular Weight:497.421
Hs Code.:

Synonyms:methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Suppliers and Price of methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

There total 5 articles about methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 367260-28-4
methyl 2-[(2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-3-cyano-1-naphthoate

: 367260-30-8
methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.333333h; Heating;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 147643-57-0
(2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid

: 367260-30-8
methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / N,N-diisopropylethylamine; 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Heating

2: lithium aluminum hydride / diethyl ether; tetrahydrofuran / 3 h / Heating

3: sodium carbonate / dioxane; H₂O / 1 h

4: sodium hydride / dimethylformamide; tetrahydrofuran / 0.5 h / 50 - 60 °C

5: 1.5 g / trifluoroacetic acid / CH₂Cl₂ / 0.33 h / Heating

With dmap; lithium aluminium tetrahydride; sodium hydride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263862-16-4
methyl 3-cyano-2-methyl-1-naphthoate

: 367260-30-8
methyl 3-cyano-2-[(2-{[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}ethoxy)methyl]-1-naphthoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromosuccinimide; 2,2'-azobis(2-methylisobutyronitrile) / CCl₄ / 3 h / Heating

2: sodium hydride / dimethylformamide; tetrahydrofuran / 0.5 h / 50 - 60 °C

3: 1.5 g / trifluoroacetic acid / CH₂Cl₂ / 0.33 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(2-methylisobutyronitrile); sodium hydride; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.015