(3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid

Base Information

• Chemical Name: (3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid
• CAS No.: 1193091-70-1
• Molecular Formula: C₂₃H₂₁ClFNO₅S
• Molecular Weight: 477.941

Synonyms:(3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid

Chemical Property of (3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid

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Technology Process of (3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid

There total 1 articles about (3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

(4R,6S)-6-[(E)-2-(7-chloro-6-fluoro-4-(3-methoxyphenylthio)quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one → (3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid (1193091-70-1)

Guidance literature:

(4R,6S)-6-[(E)-2-(7-chloro-6-fluoro-4-(3-methoxyphenylthio)quinoline-3-yl)-ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one; With methanol; potassium hydroxide; at 10 ℃;

With hydrogenchloride; at 25 ℃; pH=2;

Reference yield:

(3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid (1193091-70-1) → 2C23H20ClFNO5S(1-)*Ca(2+)

Guidance literature:

(3R,5S)-7-[6-fluoro-7-chloro-4-(3-methoxyphenylthio)quinoline-3-yl]-3,5-dihydroxy-6(E)-heptenoic acid; With sodium hydroxide; In ethanol; water; at 0 ℃;

With calcium chloride; In ethanol; water; at 0 ℃; for 1h;

DOI:10.1111/j.1747-0285.2011.01198.x

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