(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Base Information

Chemical Name:(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester
CAS No.:56774-69-7
Molecular Formula:C₂₁H₃₁NO₆
Molecular Weight:393.48
Hs Code.:

Synonyms:(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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Chemical Property of (+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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Technology Process of (+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

There total 7 articles about (+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 57103-64-7,73090-17-2,73090-18-3,108913-62-8,108913-63-9,108913-64-0,108913-65-1,109785-75-3,109785-76-4
(+/-)-trans-1-<2-(2-benzyloxy-3,4-dimethyloxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

: 56774-69-7
(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: With perchloric acid; hydrogen; palladium on activated charcoal; In ethanol; at 28 ℃; for 4.5h; under 760 Torr;
DOI:10.1016/0040-4020(80)80049-4

Reference yield:

: 56774-66-4
2-(benzyloxy)-3,4-dimethoxyphenacyl bromide

: 56774-69-7
(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: anhydrous K₂CO₃ / benzene / 2 h / 50 °C

2: NaBH₄ / ethanol / 15 h / Ambient temperature

3: Hg(OAc)2-EDTA / aq. acetic acid / 1.5 h / Heating

4: 90 percent / H₂ / 10 percent Pd-C / ethanol; aq. HClO₄ / 3 h / 760 Torr / Ambient temperature

With sodium tetrahydroborate; Hg(OAc)2*EDTA; hydrogen; potassium carbonate; palladium on activated charcoal; In perchloric acid; ethanol; acetic acid; benzene;
DOI:10.1248/cpb.34.496

Reference yield:

: 56774-65-3,96790-30-6,96790-31-7,97673-06-8,109009-07-6
((3S,4S)-6-Ethoxy-3-ethyl-2,3,4,5-tetrahydro-pyridin-4-yl)-acetic acid ethyl ester

: 56774-69-7
(+/-)-trans-1-(3,4-dimethyloxy-2-hydroxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol / 27 h / Ambient temperature

2: anhydrous K₂CO₃ / benzene / 2 h / 50 °C

3: NaBH₄ / ethanol / 15 h / Ambient temperature

4: Hg(OAc)2-EDTA / aq. acetic acid / 1.5 h / Heating

5: 90 percent / H₂ / 10 percent Pd-C / ethanol; aq. HClO₄ / 3 h / 760 Torr / Ambient temperature

With sodium tetrahydroborate; Hg(OAc)2*EDTA; hydrogen; potassium carbonate; palladium on activated charcoal; In perchloric acid; ethanol; acetic acid; benzene;
DOI:10.1248/cpb.34.496