aplysinamisine III

Base Information

• Chemical Name: aplysinamisine III
• CAS No.: 150417-69-9
• Molecular Formula: C₂₃H₂₅Br₄N₃O₇
• Molecular Weight: 775.083
• Mol file: 150417-69-9.mol

Synonyms:(+)-AplysinamisineIII; Aplysinamisine III

Chemical Property of aplysinamisine III

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 142.20000
• Density: 1.97g/cm³
• LogP: 4.35430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of aplysinamisine III

There total 1 articles about aplysinamisine III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 3-{3-[4-(1-acetoxy-2-acetylamino-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester (150417-70-2) → 7,9-Dibromo-10-hydroxy-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carboxylic acid {3-[4-(2-acetylamino-1-hydroxy-ethyl)-2,6-dibromo-phenoxy]-propyl}-amide (150417-69-9) + Acetic acid 3-{3-[4-(2-acetylamino-1-hydroxy-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester

Guidance literature:

With hydrogenchloride; In methanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)91843-5

Reference yield:

7,9-Dibromo-10-hydroxy-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carboxylic acid {3-[4-(2-acetylamino-1-hydroxy-ethyl)-2,6-dibromo-phenoxy]-propyl}-amide (150417-69-9) → Acetic acid 3-{3-[4-(2-acetylamino-1-hydroxy-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 100 mg / pyridine / Ambient temperature

2: 30 mg / HCl / methanol / 24 h / Ambient temperature

With hydrogenchloride; In pyridine; methanol;

DOI:10.1016/S0040-4020(01)91843-5

Reference yield:

acetic anhydride (108-24-7) + 7,9-Dibromo-10-hydroxy-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,6,8-triene-3-carboxylic acid {3-[4-(2-acetylamino-1-hydroxy-ethyl)-2,6-dibromo-phenoxy]-propyl}-amide (150417-69-9) → Acetic acid 3-{3-[4-(1-acetoxy-2-acetylamino-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester (150417-70-2)

Guidance literature:

In pyridine; Ambient temperature;

DOI:10.1016/S0040-4020(01)91843-5

upstream raw materials:

Acetic acid 3-{3-[4-(1-acetoxy-2-acetylamino-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester

Downstream raw materials:

Acetic acid 3-{3-[4-(1-acetoxy-2-acetylamino-ethyl)-2,6-dibromo-phenoxy]-propylcarbamoyl}-7,9-dibromo-8-methoxy-1-oxa-2-aza-spiro[4.5]deca-2,7,9-trien-6-yl ester

Refernces