3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

Base Information

Chemical Name:3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one
CAS No.:1353884-43-1
Molecular Formula:C₂₂H₁₉ClN₄O₃
Molecular Weight:422.871
Hs Code.:

Synonyms:3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

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Chemical Property of 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

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Technology Process of 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

There total 4 articles about 3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34035-03-5
5-(4-chlorophenyl)-2-furaldehyde

: 1353884-43-1
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; hydroxylamine hydrochloride / 20 °C / Inert atmosphere

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 1 h / 60 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200238g

Reference yield:

: C₂₇H₂₇ClN₄O₅

: 1353884-43-1
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ml200238g

Reference yield:

: 1353884-82-8
C₂₆H₂₉ClN₄O₄

: 1353884-43-1
3-(5-(4-chlorophenyl)furan-2-yl)-4-(4-(piperazin-1-yl)phenyl)-1,2,4-oxadiazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With caesium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200238g