tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate
CAS No.:1188914-93-3
Molecular Formula:C₂₂H₃₀N₆O₄
Molecular Weight:442.518
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1188914-92-2
4-(4-chloro-6-morpholinyl-1,3,5-triazine-2-yl)pyridazine-1-carboxylic acid tert-butyl ester

: 214360-76-6
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

: 1188914-93-3
tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

Guidance literature:: With sodium carbonate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; for 3h; Inert atmosphere of nitrogen; Reflux;

Reference yield: 73.7%

: 1188914-92-2
4-(4-chloro-6-morpholinyl-1,3,5-triazine-2-yl)pyridazine-1-carboxylic acid tert-butyl ester

: 87199-18-6
3-hydroxyphenylboronic acid

: 1188914-93-3
tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

Guidance literature:: With tetrabutylammomium bromide; palladium diacetate; caesium carbonate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Sealed tube; Microwave irradiation;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1188914-93-3
tert-butyl 4-(4-(3-hydroxyphenyl)-6-morpholino-1,3,5-triazin-2-yl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1.33 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: caesium carbonate; palladium diacetate; tricyclohexylphosphine; tetrabutylammomium bromide / water; N,N-dimethyl-formamide / 0.5 h / 150 °C / Sealed tube; Microwave irradiation

With tetrabutylammomium bromide; palladium diacetate; potassium carbonate; caesium carbonate; tricyclohexylphosphine; In dichloromethane; water; N,N-dimethyl-formamide;