N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine
• CAS No.: 1445856-79-0
• Molecular Formula: C₂₆H₂₇N₉O
• Molecular Weight: 481.56

Synonyms:N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine

Chemical Property of N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine

There total 8 articles about N⁴-(5-cyclopropyl-1H-pyrazol-3-yl)-N²-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine + 1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethanamine (1445856-53-0) → N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine (1445856-79-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 120 ℃; Sealed tube;

Reference yield:

6-(1-ethoxyvinyl)-3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridine (1445856-55-2) → N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine (1445856-79-0)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / water; methanol / 0.5 h / 20 °C

2: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 20 °C

3: zinc; ammonium chloride; acetic acid / methanol / 4 h / 60 °C

4: N-ethyl-N,N-diisopropylamine / 120 °C / Sealed tube

With hydrogenchloride; hydroxylamine hydrochloride; sodium acetate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In methanol; water;

Reference yield:

6-chloro-3H-imidazo [4,5-c] pyridine (2589-11-9) → N4-(5-cyclopropyl-1H-pyrazol-3-yl)-N2-(1-(3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridin-6-yl)ethyl)pyrimidine-2,4-diamine (1445856-79-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1-methyl-pyrrolidin-2-one / 72 h / 140 °C

3.1: hydrogenchloride / water; methanol / 0.5 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 20 °C

5.1: zinc; ammonium chloride; acetic acid / methanol / 4 h / 60 °C

6.1: N-ethyl-N,N-diisopropylamine / 120 °C / Sealed tube

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium acetate; sodium hydride; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; mineral oil;

upstream raw materials:

6-chloro-pyridine-3,4-diamine

6-chloro-3H-imidazo [4,5-c] pyridine

6-chloro-3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridine

6-(1-ethoxyvinyl)-3-(4-methoxybenzyl)-3H-imidazo[4,5-c]pyridine

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