3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

Base Information

Chemical Name:3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole
CAS No.:1391944-26-5
Molecular Formula:C₂₂H₁₀Cl₂F₄N₄O₂
Molecular Weight:509.247
Hs Code.:

Synonyms:3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

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Chemical Property of 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

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Technology Process of 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

There total 10 articles about 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1391944-29-8
C₂₀H₉Cl₂F₄N₃O₂

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 1391944-26-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

Guidance literature:: C₂₀H₉Cl₂F₄N₃O₂; With methanol; sodium methylate; at 20 ℃; for 0.0833333h; Inert atmosphere;

[(p-methylphenyl)sulfonylmethyl]isonitrile; In methanol; for 2h; Reflux;

Reference yield:

: 1391944-17-4
ethyl 3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylate

: 1391944-26-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 1 h / Reflux

1.2: pH 2

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Cooling with ice

4.1: sodium methylate; methanol / 0.08 h / 20 °C / Inert atmosphere

4.2: 2 h / Reflux

With methanol; lithium aluminium tetrahydride; water; sodium methylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 1391943-37-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)isoxazole-4-carboxylic acid

: 1391944-26-5
3-(2-chloro-6-fluorophenyl)-5-(1-(3-chlorophenyl)-5-(trifluoromethyl)-1H-pyrazol-4-yl)-4-(oxazol-5-yl)isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Cooling with ice

3.1: sodium methylate; methanol / 0.08 h / 20 °C / Inert atmosphere

3.2: 2 h / Reflux

With methanol; lithium aluminium tetrahydride; sodium methylate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;