(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

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Chemical Name:(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
CAS No.:166974-27-2
Molecular Formula:C₂₄H₂₁Cl₂N₃O₅
Molecular Weight:502.354
Hs Code.:

Synonyms:(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

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Chemical Property of (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

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Technology Process of (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

There total 3 articles about (E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 166974-61-4
1-tert-butoxycarbonyl-3-formyl-4,6-dichloroindole-2-carboxylic acid ethyl ester

: 166974-95-4
3-oxo-2-phenylpyrazolidine-1-carboxylic acid tert-butyl ester

: 4-(4,6-dichloro-1-oxo-3,8-dihydro-1H-2-oxa-8-aza-cyclopenta[a]inden-3-yl)-3-oxo-2-phenyl-pyrazolidine-1-carboxylic acid tert-butyl ester

: 166974-27-2
(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

: 3-(1-tert-butoxycarbonyl-3-oxo-2-phenyl-pyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid ethyl ester

Guidance literature:: 3-oxo-2-phenylpyrazolidine-1-carboxylic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -20 ℃; for 0.5h;

1-tert-butoxycarbonyl-3-formyl-4,6-dichloroindole-2-carboxylic acid ethyl ester; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/S0014-827X(01)01141-7

Reference yield:

: 153435-96-2
ethyl-3-formyl-4,6-dichloro-indole-2-carboxylate

: 166974-27-2
(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 91 percent / DMAP / CH₂Cl₂ / 1 h

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -20 °C

2.2: 27 percent / tetrahydrofuran / 2 h / 20 °C

With dmap; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0014-827X(01)01141-7

Reference yield:

: 42116-43-8
tert-butyl 2-phenylhydrazine-1-carboxylate

: 166974-27-2
(E)-3-(1-tert-butoxycarbonyl-3-oxo-2-phenylpyrazolidin-4-ylidenemethyl)-4,6-dichloro-1H-indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / K₂CO₃ / dimethylformamide

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -20 °C

2.2: 27 percent / tetrahydrofuran / 2 h / 20 °C

With potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0014-827X(01)01141-7