((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Base Information

Chemical Name:((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane
CAS No.:115352-43-7
Molecular Formula:C₂₂H₃₈O₄Si
Molecular Weight:394.627
Hs Code.:

Synonyms:((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

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Chemical Property of ((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

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Technology Process of ((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

There total 4 articles about ((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93662-86-3
isopropyl 2,4,6-tri-O-acetyl-3-deoxy-α-D-erythro-hex-2-enopyranoside

: 115352-43-7
((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

2: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 24 h

3: imidazole / dimethylformamide / Ambient temperature

4: 1.) sodium hydride / 1.) THF, 2.) THF, DMF, 6.5 h

With 1H-imidazole; lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86915-5

Reference yield:

: 115352-42-6
2-propyl 3,4-dideoxy-α-D-erythro-hex-3-enopyranoside

: 115352-43-7
((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 24 h

2: imidazole / dimethylformamide / Ambient temperature

3: 1.) sodium hydride / 1.) THF, 2.) THF, DMF, 6.5 h

With 1H-imidazole; hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)86915-5

Reference yield:

: 3366-47-0
2,3,4,6-tetra-O-acetyl-1,5-anhydro-D-arabinohex-1-enopyranose

: 115352-43-7
((2S,5R,6S)-5-Benzyloxy-6-isopropoxy-tetrahydro-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 63.1 percent / BF₃*Et₂O / benzene / 0.17 h / Ambient temperature

2: LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

3: 96 percent / hydrogen / 10percent Pd/C / ethyl acetate / 24 h

4: imidazole / dimethylformamide / Ambient temperature

5: 1.) sodium hydride / 1.) THF, 2.) THF, DMF, 6.5 h

With 1H-imidazole; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86915-5