N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Base Information

Chemical Name:N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide
CAS No.:1186240-87-8
Molecular Formula:C₃₇H₄₈N₆O₇S
Molecular Weight:720.89
Hs Code.:

N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Synonyms:N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Chemical Property of N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

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Technology Process of N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

There total 23 articles about N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61396-67-6
rac-3-(2-nitrophenoxy)-1,2-propanediol

: 1186240-87-8
N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 2 h / 20 °C / Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 - -65 °C

2.2: -78 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 2250.23 - 3750.38 Torr

4.1: pyridine / 48 h / 20 °C

5.1: water / ethanol

6.1: sodium hydroxide / tetrabutyl-ammonium chloride / dichloromethane; water / 4.5 h / 20 °C / Cooling with ice

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

8.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.5 h / 20 °C

8.2: 18 h / 20 °C

With pyridine; oxalyl dichloride; water; hydrogen; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; tetrabutyl-ammonium chloride; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 1186241-04-2
2-[[4-[(4-Methoxy-2,6-dimethyl-phenyl)sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid

: N-[[4-(4-methylpiperazin-1-yl)-piperidin-4-yl]methyl]pyridine-4-carboxylic acid amide dihydrochloride

: 1186240-87-8
N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: 2-[[4-[(4-Methoxy-2,6-dimethyl-phenyl)sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1.5h;

N-[[4-(4-methylpiperazin-1-yl)-piperidin-4-yl]methyl]pyridine-4-carboxylic acid amide dihydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1186240-87-8
N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol; water / 0.5 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C

3.1: triethylamine / dichloromethane / 2 h / 25 °C

4.1: hydrogenchloride / 1,4-dioxane / 3 h / 0 - 25 °C

5.1: 1,1'-carbonyldiimidazole / dichloromethane / 1.5 h / 20 °C

5.2: 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; water;