methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

Base Information

Chemical Name:methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate
CAS No.:188001-47-0
Molecular Formula:C₂₉H₂₉NO₇
Molecular Weight:503.552
Hs Code.:

Synonyms:methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

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Chemical Property of methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

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Technology Process of methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

There total 8 articles about methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3840-27-5
2,5-dimethoxybenzyl chloride

: 195244-91-8
6-Ethoxy-4-(4-methoxy-phenyl)-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester

: 188001-47-0
methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00319-3

Reference yield:

: 59255-66-2
N-(tert-butoxycarbonyl)-4-ethoxyaniline

: 188001-47-0
methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 20 percent / t-BuLi / tetrahydrofuran

2: 80 percent / Dess-MArtin periodinane / CH₂Cl₂

3: 90 percent / 5N HCl / dioxane

4: 90 percent / EtNH(i-Pr)2 / dimethylformamide

5: 87 percent / NaOMe / methanol

6: 72 percent / K₂CO₃ / dimethylformamide

With hydrogenchloride; tert.-butyl lithium; sodium methylate; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00319-3

Reference yield:

: 156-43-4
4-Ethoxyaniline

: 188001-47-0
methyl 4-(4-methoxyphenyl)1,2-dihydro-6-ethoxy-1-(2,5-dimethoxybenzyl)-2-oxoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / tetrahydrofuran

2: 20 percent / t-BuLi / tetrahydrofuran

3: 80 percent / Dess-MArtin periodinane / CH₂Cl₂

4: 90 percent / 5N HCl / dioxane

5: 90 percent / EtNH(i-Pr)2 / dimethylformamide

6: 87 percent / NaOMe / methanol

7: 72 percent / K₂CO₃ / dimethylformamide

With hydrogenchloride; tert.-butyl lithium; sodium methylate; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00319-3