N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

Base Information

Chemical Name:N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide
CAS No.:1369796-24-6
Molecular Formula:C₂₈H₂₉FN₄O₃S₂
Molecular Weight:552.694
Hs Code.:

Synonyms:N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

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Chemical Property of N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

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Technology Process of N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

There total 13 articles about N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369796-67-7
N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-2-hydroxy-8-(4-methylthiazol-5-yl)octanamide

: 1369796-24-6
N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2.5h;

Reference yield:

: 4117-10-6
6-hepten-1-ol

: 1369796-24-6
N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

Guidance literature:: Multi-step reaction with 10 steps

1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C

2: ethyl acetate; water / 24 h / 20 °C

3: hydrogenchloride / 18.08 h / -78 - -10 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 20 h / 100 °C / sealed tube; Inert atmosphere

6: hydrogen / palladium 10% on activated carbon / ethanol / 760.05 Torr

7: toluene-4-sulfonic acid; methanol / 1 h / 20 °C

8: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 22 h / 20 °C

10: Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C

With hydrogenchloride; methanol; water; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; pyridinium chlorochromate; trifluoroacetic acid; lithium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 17206-61-0
hept-6-enal

: 1369796-24-6
N-((5-(4-((3-fluorobenzyl)oxy)phenyl)-1,3,4-thiadiazol-2-yl)methyl)-8-(4-methylthiazol-5-yl)-2-oxooctanamide

Guidance literature:: Multi-step reaction with 9 steps

1: ethyl acetate; water / 24 h / 20 °C

2: hydrogenchloride / 18.08 h / -78 - -10 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / toluene / 20 h / 100 °C / sealed tube; Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / ethanol / 760.05 Torr

6: toluene-4-sulfonic acid; methanol / 1 h / 20 °C

7: water; lithium hydroxide / tetrahydrofuran / 2 h / 20 °C

8: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 22 h / 20 °C

9: Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C

With hydrogenchloride; methanol; water; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;