3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Base Information

Chemical Name:3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide
CAS No.:1351238-70-4
Molecular Formula:C₂₅H₂₀ClN₅O₂S
Molecular Weight:489.985
Hs Code.:

Synonyms:3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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Chemical Property of 3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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Technology Process of 3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

There total 14 articles about 3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 872090-71-6
N-(3-amino-4-methylphenyl)-3-(2-cyanopropan-2-yl)benzamide

: 1351238-69-1
3-chlorothieno[2,3-b]pyrazine-6-carbonyl chloride

: 1351238-70-4
3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1351238-58-8
methyl 5-(2,4-dimethoxybenzylamino)-4-nitrothiophene-2-carboxylate

: 1351238-70-4
3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: triethylamine / tetrahydrofuran / 20 - 40 °C

3: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

4: triethylamine / dichloromethane / 3 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 80 °C

6: trichlorophosphate / 120 h / Reflux

7: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

8: thionyl chloride / 2 h / 80 °C

9: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; triethylamine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: methyl 5-amino-4-nitrothiophene-2-carboxylate

: 1351238-70-4
3-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / tetrahydrofuran / 20 - 40 °C

2: hydrogen / palladium on activated charcoal / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 80 °C

5: trichlorophosphate / 120 h / Reflux

6: sodium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

7: thionyl chloride / 2 h / 80 °C

8: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; triethylamine; sodium hydroxide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;