methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

Base Information

Chemical Name:methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate
CAS No.:135604-81-8
Molecular Formula:C₂₅H₃₈O₄
Molecular Weight:402.574
Hs Code.:

methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-<sup>(19)</sup>-trien-24-oate

Synonyms:methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

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Chemical Property of methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

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Technology Process of methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

There total 6 articles about methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (R)-4-{(1R,3aS,7aR)-4-[2-[(3S,5R)-5-Acetoxy-3-hydroperoxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-octahydro-inden-1-yl}-pentanoic acid methyl ester

: 135604-81-8
methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; for 1.33333h; Ambient temperature;
DOI:10.1016/0039-128X(91)90052-W

Reference yield:

: 85198-71-6
methyl 1α,3β-diacetoxychol-5-en-24-oate

: 135604-81-8
methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NBS, AIBN, 2.) 2,4,6-collidine

2: 75 percent / KOH / methanol / 2 h / Ambient temperature

3: 84 percent / 1,1,3,3-tetramethylguanidine / 0.5 h / Heating

4: 1.) irradiation, Et₂O, 2.) hexane, THF, 9 days, R_.T_.

With 2,4,6-trimethyl-pyridine; potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N,N,N',N'-tetramethylguanidine; In methanol;
DOI:10.1016/0039-128X(94)90009-4

Reference yield:

: methyl 1α,3β-diacetoxy-3',5'-dioxo-4'-phenyl-5,8-<1,2>epi-<1,2,4>triazolo-5α,8α-chol-6-en-24-oate

: 135604-81-8
methyl (5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10-⁽¹⁹⁾-trien-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / KOH / methanol / 2 h / Ambient temperature

2: 84 percent / 1,1,3,3-tetramethylguanidine / 0.5 h / Heating

3: 1.) irradiation, Et₂O, 2.) hexane, THF, 9 days, R_.T_.

With potassium hydroxide; N,N,N',N'-tetramethylguanidine; In methanol;
DOI:10.1016/0039-128X(94)90009-4