2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

Base Information

Chemical Name:2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide
CAS No.:1613439-87-4
Molecular Formula:C₁₉H₁₄F₆N₂O₃
Molecular Weight:432.322
Hs Code.:

Synonyms:2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

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Chemical Property of 2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

Chemical Property:

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Technology Process of 2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

There total 4 articles about 2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₀H₃ClF₆O₂

: 33322-60-0
3-amino-N,N-dimethylbenzamide

: 1613439-87-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1002/anie.201400147

Reference yield:

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 1613439-87-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium / tetrahydrofuran / 1 h / 20 °C

1.2: 1 h / -78 - -10 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 6 h / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

4.1: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; oxalyl dichloride; water; magnesium; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201400147

Reference yield:

: 402568-10-9
ethyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-oxoacetate

: 1613439-87-4
2-(3,5-bis(trifluoromethyl)phenyl)-N-(3-(N,N-dimethylaminocarbonylphenyl))-2-oxoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / tetrahydrofuran / 6 h / Reflux

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

3: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201400147