(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

Base Information

Chemical Name:(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride
CAS No.:701266-77-5
Molecular Formula:C₁₈H₁₉F₂N₃O₃*ClH
Molecular Weight:399.825
Hs Code.:

Synonyms:(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

Chemical Property:

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Technology Process of (RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

There total 6 articles about (RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: (RS)-[(4-{[2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetylamino]-methyl}-phenyl)-imino-methyl]-carbamic acid benzyl ester

: 701266-77-5
(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 2h; under 760.051 Torr;

Reference yield:

: 701266-71-9
tert-butyl-(2,4-difluoro-phenoxy)-diphenyl-silane

: 701266-77-5
(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / 1,2-dimethoxyethane; hexane / 2 h / -70 °C

1.2: 4 h / -70 - 0 °C

2.1: silver(l) oxide / toluene / 68 h / 90 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 65 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 0 - 20 °C

5.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

With hydrogenchloride; lithium hydroxide; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; silver(l) oxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; ethanol; hexane; water; toluene;

Reference yield:

: 701266-73-1
(RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-ethoxy-acetic acid ethyl ester

: 701266-77-5
(RS)-N-(4-carbamimidoyl-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 65 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 1 h / 0 - 20 °C

3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); ethanol; water;