N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

Base Information

Chemical Name:N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide
CAS No.:1612842-17-7
Molecular Formula:C₂₄H₂₂ClFN₄O₅S
Molecular Weight:532.98
Hs Code.:

Synonyms:N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

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Chemical Property of N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

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Technology Process of N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

There total 4 articles about N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025721-01-0
4-(4-amino-2-fluorophenoxy)-3-chloropyridine-2-carboxamide

: 1612842-11-1
C₁₂H₁₅NO₄S

: 1612842-17-7
N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1612842-17-7
N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: potassium phosphate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

3: potassium hydroxide / methanol; water / 3 h / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; potassium phosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.056

Reference yield:

: 78374-64-8
ethyl 2-(N-p-tolylsulfamoyl)acetate

: 1612842-17-7
N-(4-((2-carbamoyl-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-2-(p-tolyl)-1,2-thiazinane-6-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere

2: potassium hydroxide / methanol; water / 3 h / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With dmap; potassium phosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.056