5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

Base Information

Chemical Name:5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine
CAS No.:402518-11-0
Molecular Formula:C₄₂H₄₄N₂O₈
Molecular Weight:704.82
Hs Code.:

5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N<sup>3</sup>-(4-t-butylbenzoyl) uridine

Synonyms:5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

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Technology Process of 5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

There total 4 articles about 5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 402518-08-5
(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

: 402518-11-0
5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

Guidance literature:: With triethylamine; In pyridine;
DOI:10.1016/S0040-4020(01)00745-1

Reference yield:

: 1710-98-1
p-tert-butyl benzoyl chloride

: 402518-11-0
5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 19 mg / tetrabutylammonium bromide; Na₂CO₃ / CH₂Cl₂; H₂O / 20 °C

2: 69 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h

3: 73 percent / Et₃N / pyridine

With tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00745-1

Reference yield:

: 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-deoxy-2'-C-methyluridine

: 402518-11-0
5'-O-dimethoxytrityl-(2'S)-2'-deoxy-2'-C-methyl-N³-(4-t-butylbenzoyl) uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 19 mg / tetrabutylammonium bromide; Na₂CO₃ / CH₂Cl₂; H₂O / 20 °C

2: 69 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.08 h

3: 73 percent / Et₃N / pyridine

With tetrabutyl ammonium fluoride; tetrabutylammomium bromide; sodium carbonate; triethylamine; In tetrahydrofuran; pyridine; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00745-1