methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

Base Information

Chemical Name:methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate
CAS No.:1034837-07-4
Molecular Formula:C₂₀H₁₈ClF₂N₃O₂
Molecular Weight:405.832
Hs Code.:

Synonyms:methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

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Chemical Property of methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

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Technology Process of methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

There total 3 articles about methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 940865-76-9
2-chloro-4-{[(2,3-difluorophenyl)methyl] [(3S)-3-pyrrolidinyl]amino}benzonitrile

: 79-22-1
methyl chloroformate

: 1034837-07-4
methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 1h;

Reference yield:

: 1034856-41-1
C₁₃H₁₄ClN₃O₂

: 113211-94-2
2,3-difluorobenzyl bromide

: 1034837-07-4
methyl (3S)-3-{(3-chloro-4-cyanophenyl)[(2,3-difluorophenyl)methyl]amino}-1-pyrrolidinecarboxylate

Guidance literature:: C₁₃H₁₄ClN₃O₂; With sodium hydride; In N,N-dimethyl-formamide; mineral oil;

2,3-difluorobenzyl bromide; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2009.10.092