N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

Base Information

Chemical Name:N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide
CAS No.:1380421-82-8
Molecular Formula:C₂₇H₂₁Cl₂N₅O₄S
Molecular Weight:582.467
Hs Code.:

Synonyms:N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

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Chemical Property of N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

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Technology Process of N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

There total 3 articles about N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1380421-72-6
N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-1,3-thiazolidine-carboxamide

: 104-88-1
4-chlorobenzaldehyde

: 1380421-82-8
N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 6.3h; Reflux;
DOI:10.4067/s0717-97072012000100018

Reference yield:

: 1016495-42-3
N₁-(3-chloropropyl)-6-nitroindazole

: 1380421-82-8
N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 4.3 h / 20 °C

2: acetic acid / ethanol / 4.3 h / Reflux

3: zinc(II) chloride / ethanol / 7.3 h / 20 °C / Reflux

4: sodium ethanolate / ethanol / 6.3 h / 20 °C / Reflux

With sodium ethanolate; acetic acid; zinc(II) chloride; In ethanol; 4: Knoevenagel condensation;
DOI:10.4067/s0717-97072012000100018

Reference yield:

: 1360889-25-3
N₁-{3-(aminocarbamyl)propyl}-6-nitroindazole

: 1380421-82-8
N-[3-(1H-6-nitroindazol-1-yl)-propyl]-2-(4-chlorophenyl)-4-oxo-5-(4-chloro benzylidene)-1,3-thiazolidine-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / ethanol / 4.3 h / Reflux

2: zinc(II) chloride / ethanol / 7.3 h / 20 °C / Reflux

3: sodium ethanolate / ethanol / 6.3 h / 20 °C / Reflux

With sodium ethanolate; acetic acid; zinc(II) chloride; In ethanol; 3: Knoevenagel condensation;
DOI:10.4067/s0717-97072012000100018