Technology Process of Boc-(N-Me)Lys(CONH-Ph-o-Me)-OH
There total 5 articles about Boc-(N-Me)Lys(CONH-Ph-o-Me)-OH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 2.8 g / NEt3 / CH2Cl2 / 72 h / Ambient temperature
2: 1.) p-toluenesulfonic acid, 2.) triethylsilane, TFA / 1.) toluene, reflux, 48 h, 2.) CHCl3, RT, 44 h
3: H2 / 10percent Pd/C / methanol / 18 h
4: NEt3 / methanol; H2O
5: 1.) hydrazine hydrate, 2.) NEt3 / 1.) EtOH, reflux, 3 h, 2.) DMF, 1.25 h
With
triethylsilane; hydrogen; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2 / 10percent Pd/C / methanol / 18 h
2: NEt3 / methanol; H2O
3: 1.) hydrazine hydrate, 2.) NEt3 / 1.) EtOH, reflux, 3 h, 2.) DMF, 1.25 h
With
hydrogen; hydrazine hydrate; triethylamine;
palladium on activated charcoal;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) p-toluenesulfonic acid, 2.) triethylsilane, TFA / 1.) toluene, reflux, 48 h, 2.) CHCl3, RT, 44 h
2: H2 / 10percent Pd/C / methanol / 18 h
3: NEt3 / methanol; H2O
4: 1.) hydrazine hydrate, 2.) NEt3 / 1.) EtOH, reflux, 3 h, 2.) DMF, 1.25 h
With
triethylsilane; hydrogen; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; water;
![N<sub>2</sub>-[(benzyloxy)carbonyl]-L-lysine](/Databaselist/images/loading.webp)
