2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

Base Information

Chemical Name:2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile
CAS No.:181931-91-9
Molecular Formula:C₂₅H₂₄N₂O₃
Molecular Weight:400.477
Hs Code.:

Synonyms:2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

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Chemical Property of 2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

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Technology Process of 2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

There total 8 articles about 2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60032-63-5
4-hydroxy-3-iodo-benzaldehyde

: 181931-91-9
2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

2: 1.2 g / toluene / 48 h / Heating

3: 0.28 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2068.6 Torr

4: 89 percent / Amberlyst-15 / 1.) reflux, 2,5 h, 2.) RT, overnight

5: BF₃*Et₂O / CH₂Cl₂ / 1 h

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; amberlyst-15; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960230h

Reference yield:

: 6813-61-2
2-(benzoylamino)-4-pentynoic acid

: 181931-91-9
2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) pyridine, 2.) H₂O / 1.) 90 deg c, 1 h, 2.) from 85 to 90 deg C, 20 min

2: trifluoroacetic acid anhydride / trifluoroacetic acid / 6 h / 35 - 40 °C

3: 65 percent / Cu₂O, (PPh₃)2PdCl₂, pyridine / Heating

4: 1.2 g / toluene / 48 h / Heating

5: 0.28 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2068.6 Torr

6: 89 percent / Amberlyst-15 / 1.) reflux, 2,5 h, 2.) RT, overnight

7: BF₃*Et₂O / CH₂Cl₂ / 1 h

With pyridine; copper(I) oxide; bis-triphenylphosphine-palladium(II) chloride; amberlyst-15; boron trifluoride diethyl etherate; water; hydrogen; trifluoroacetic anhydride; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene; trifluoroacetic acid;
DOI:10.1021/jm960230h

Reference yield:

: 132646-34-5
2-(5-methyl-2-phenyl-4-oxazolyl)methyl-5-benzofurancarboxaldehyde

: 181931-91-9
2-ethoxy-4-{2-[(5-methyl-2-phenyloxazol-4-yl)-methyl]benzofuran-5-yl}butyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.2 g / toluene / 48 h / Heating

2: 0.28 g / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 2068.6 Torr

3: 89 percent / Amberlyst-15 / 1.) reflux, 2,5 h, 2.) RT, overnight

4: BF₃*Et₂O / CH₂Cl₂ / 1 h

With amberlyst-15; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jm960230h