(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

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Chemical Name:(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate
CAS No.:1390672-79-3
Molecular Formula:C₄₁H₅₀N₄O₇S
Molecular Weight:742.937
Hs Code.:

Synonyms:(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

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Chemical Property of (S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

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Technology Process of (S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

There total 7 articles about (S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1390672-73-7
SCN-Asp(OtBu)-OtBu

: 1390672-78-2
C₂₈H₂₉N₃O₃*ClH

: 1390672-79-3
(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1039/c2ob25693b

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1390672-79-3
(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran

2.1: triethylamine / dichloromethane

3.1: sodium azide / N,N-dimethyl-formamide / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 8 h / Reflux

4.2: 16 h / Reflux

5.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h

6.1: hydrogenchloride; methanol / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

With hydrogenchloride; methanol; sodium azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25693b

Reference yield:

: 117049-14-6
tert-butyl N-[(1S)-2-hydroxy-1-phenylethyl]carbamate

: 1390672-79-3
(S)-di-tert-butyl 2-{3-[(S)-1-{[((9H-fluoren-9-yl)methoxy)carbonyl]pyrrolidine-2-carboxamido}-1-phenylethyl]thioureido}succinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane

2.1: sodium azide / N,N-dimethyl-formamide / 60 °C

3.1: triphenylphosphine / tetrahydrofuran / 8 h / Reflux

3.2: 16 h / Reflux

4.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 24 h

5.1: hydrogenchloride; methanol / 1 h / 20 °C

6.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

With hydrogenchloride; methanol; sodium azide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c2ob25693b